| Date | Location | Result | |
| Dec 18, 2021 | Mobile, Ala. | Liberty 56, Eastern Michigan 20 | Box score |
| Nov 26, 2021 | Mount Pleasant, Mich | Central Michigan 31, Eastern Michigan 10 | Box score |
| Nov 16, 2021 | Ypsilanti, Mich. | Eastern Michigan 22, Western Michigan 21 | Box score |
| Nov 09, 2021 | Ypsilanti, Mich. | Ohio 34, Eastern Michigan 26 | Box score |
| Nov 02, 2021 | Toledo, Ohio | Eastern Michigan 52, Toledo 49 | Box score |
| Oct 23, 2021 | Bowling Green, Ohio | Eastern Michigan 55, Bowling Green 24 | Box score |
| Oct 16, 2021 | Ypsilanti, Mich. | Ball State 38, Eastern Michigan 31 | Box score |
| Oct 09, 2021 | Ypsilanti, Mich. | Eastern Michigan 13, Miami 12 | Box score |
| Oct 02, 2021 | DeKalb, Illinois | Northern Illinois 27, Eastern Michigan 20 | Box score |
| Sep 25, 2021 | Ypsilanti, Mich. | Eastern Michigan 59, Texas State 21 | Box score |
| Sep 18, 2021 | Amherst, Mass. | Eastern Michigan 42, Massachusetts 28 | Box score |
| Sep 11, 2021 | Madison, Wis. | Wisconsin 34, Eastern Michigan 7 | Box score |
| Sep 03, 2021 | Ypsilanti, Mich. | Eastern Michigan 35, Saint Francis 15 | Box score |